Mieszko obtained his PhD in Biomedical Sciences (2013) from the National University of Ireland at the Regenerative Medicine Institute (REMEDI). His research aimed to develop novel approaches to prolong allograft survival after cornea transplantation using lentiviral vectors to deliver genes encoding immunosuppressive factors. Next, in 2013 Mieszko begun to work as a postdoctoral researcher at the Trinity Biomedical Sciences Institute (TBSI) at Trinity College Dublin in Ireland.
His research interests are focused on regulation and modulation of immunological response induced by infections, vaccinations and during tumorigenesis in the aim to develop novel immunotherapeutics. In 2019, Mieszko completed an internship as a principal investigator in Avectas Ltd. (Ireland), a company in the field of immunooncology, testing different approaches for generating and modifying CAR-T cells. Mieszko also worked at Molecure in Warsaw as a research group leader and project manager for the use of a new small molecule USP7 inhibitor in the treatment of cancer.
Mieszko has published many articles in leading international journals in the field of immunology, immunooncology and infectious diseases (Journal of Experimental Medicine, Nature Communications, Trends in Microbiology, Mucosal Immunology). Mieszko is also a co-author of a chapter in a book titled “Pertussis: Epidemiology, Immunology, and Evolution” published by Oxford University Press (2019).